Tianeptine Sodium CAS: 30123-17-2 5-dioxide Stablon S-Dioxide Sodium Salt

HOʻohana

ʻO ka paʻakai sodium Tianeptine he antidepressant tricyclic, a ʻokoʻa kona ʻano antidepressant me nā antidepressant tricyclic kuʻuna.Hiki iā ia ke hoʻonui i ka reuptake o 5-HT i loko o ka synaptic space, a loaʻa paha ka hopena o ka hoʻomaikaʻi ʻana i ka lawe ʻana o nā neurons 5-HT.ʻAʻole pili i ka choline a i ʻole adrenaline receptors.Ua like ka antidepressant efficacy me ka tricyclic, akā ʻoi aku ka maikaʻi o ka hoʻomanawanui ma mua o ka tricyclic.I nā hoʻokolohua holoholona, ​​hiki iā ia ke hoʻonui i ka hana kuʻuna o nā cell pyramidal i hippocampus a hoʻolalelale i ko lākou hoʻihoʻi ʻana ma hope o ka hana inhibition.Hoʻonui ka Chemicalbook i ka reabsorption o ke serotonin e nā neurons i ka cerebral cortex a me ka hippocampus.ʻO ka absorption o ka sodium tineptine i loko o ka digestive tract wikiwiki a piha.Hoʻolaha wikiwiki, PPB a hiki i 94%.Ua metabolized loa ia i loko o ke akepaʻa e β-oxidation a me N-demethylation, a me ka hoʻomaʻemaʻe o ka terminal T1/2 pōkole ma 2.5h.ʻO kahi liʻiliʻi liʻiliʻi o ka lāʻau lapaʻau (8%) i hoʻokuʻu ʻia mai ka ʻōpū, ʻo ka hapa nui o kāna mau metabolites mai ka mimi.ʻO nā maʻi me ka lawa ʻole o ka renal i hoʻomaʻemaʻe i ka T1/2 no kahi hola 1 lōʻihi.