HU-210 CAS NO: 112830-95-2

ʻO HU-210 ka (--) enantiomer o 11-OH-D 8-THC-DMH, kahi kokoke i nā hana a pau o nā cannabinoids, ʻoiai ka (+) enantiomer, i kapa ʻia ʻo HU-211, ʻaʻole ia e hana ma ke ʻano he cannabinoid, akā. hana ma kahi cannabinoid ma ke ʻano he antagonist NMDA me nā hopena neuroprotective.

Hiki i ka HU-210 ke hoʻoikaika i ka hoʻonui ʻana, akā ʻaʻole ka hoʻokaʻawale ʻana, o nā moʻomeheu embryonic hippocampal neural stem cell a me progenitor cell ma o ka hoʻāla ʻana i ka CB 1 receptor, G i/o protein, a me ERK hōʻailona sequentially.Hōʻike kēia ulu aʻalolo i ka pono no ka anti-anxiety a me nā hopena anti-depressive.

Me nā cannabinoids synthetic ʻē aʻe, e like me WIN 55,212-2 a me JWH-133, pale ʻo HU-210 i ka mumū i hoʻokumu ʻia e ka maʻi a Alzheimer pili i ka beta amyloid, ma kahi o ka pale ʻana i ka hōʻino ʻana o ka naʻau a me ka nalowale o nā māka neuronal.Hoʻokomo ʻia kēia hopena anti-inflammatory e ka hoʻoulu ʻana o nā mea hoʻokipa cannabinoid, ka mea e pale ai i ka hoʻoulu ʻana o nā cell microglia inflammatory.Eia kekahi, ua hoʻopau loa nā cannabinoids i ka neurotoxicity e pili ana i ka hoʻoulu ʻana o nā cell microglial i nā ʻano ʻiole.

ʻO HU-210 kahi lāʻau hōʻeha ʻeha i loaʻa i nā hopena like me THC kūlohelohe.

ʻO ka LD50 waha o HU-210 he 5,000mg/kg i nā ʻiole a me 14,200mg/kg i nā lapeti.ʻO ka LDLO (haʻahaʻa make loa) o HU-210 i loko o ke kanaka he 143mg/kg.Kuhi ʻia ka LD50 o ka caffeine he 150-200 mg/kg.ʻAʻole i hōʻoia ʻia ʻo Delta-8-THC LD50.Ma kahi haʻawina 1973, ʻaʻole make nā ʻīlio a me nā ʻīlio i hāʻawi ʻia i 9,000 mg/kg o Delta-8-THC.