China Hot Sale CAS 7361-61-7 Xylazine cannabinoids keʻokeʻo pauka

wehewehe

ʻO Xylazine kahi agonist o α2-adrenergic receptors (Ki = 194 nM).He analog ia o clonidine, he agonist receptor α2-adrenergic i hoʻohana ʻia e hoʻemi i ke koko.Hoʻohana ʻia ʻo Xylazine no ka sedation, anesthesia, a me analgesia i nā mammals non-human.Loaʻa kēia huahana ma ke ʻano he maʻamau kuhikuhi analytical.
Mea HoʻomakaXylazine, Bayer

Hoʻohana

Antinociceptive; Alpha-2 adrenergic agonist
Hoʻohana

ʻO Xylazine kahi papa α2 o ka agonist receptor adrenergic.ʻO Xylazine kahi analoque clonidine e hana ana ma nā presynaptic a me postsynaptic receptors ma ke ʻano he 2-adrenergic agonist.
Kaʻina Hana Hana

ʻO 2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), i hoʻomākaukau ʻia mai 2,6-dimethylaniline me thiophosgene, ua hoʻohui ʻia i ka dropwise i loko o 15 min i kahi hoʻokuʻu maikaʻi ʻia o 15.0 g (0.2 mole) o 3-aminopropanol-1 i loko. 100 ml o ka etera.Ua hoʻomaka ka etera e paila.Hoʻomau ʻia ka hoʻoulu ʻana ma lalo o ka reflux no 30 mau minuke, a laila hoʻopau ʻia ka ether.Ua mālama ʻia ke koena me 100 ml o ka waika hydrochloric concentrated a hoʻolapalapa ʻia ma lalo o ka reflux no 30 min.Ma hope o ka hoʻoluʻu ʻana, ua hoʻoheheʻe ʻia me ka wai, kānana ʻole ʻia mai nā haumia, a ua hoʻoheheʻe ʻia ke kumu e ka hoʻohui ʻana o ka solution sodium hydroxide concentrated.Ke hana hou ia mai benzene-ligroin, ka mea i hoʻohui ʻia 2-(2,6- dimethyl-phenylamino) -4H-5,6-dihydro-1,3-thiazine, helu heheʻe 140-142°C (hua 90% o ka theoretical. ).
Hana Lapaau

Analgesic, Anesthetic

Ka wehewehe nui

Hiki ke hoʻoheheʻe ʻia ka Xylazine i loko o ka methanol (50 mg/ml), e hāʻawi ana i kahi hopena akaka a kala ʻole.Hiki ke hoʻoheheʻe ʻia i ka waika HCl dilute a me ka chloroform.ʻAʻole hiki ke hoʻoheheʻe ʻia ʻo Xylazine i loko o ka wai a me nā hopena alkali.
Nā Hana Biochem/physiol

ʻO Xylazine ke hoʻohana pū ʻia me ka ketamine i manaʻo ʻia he mea hoʻomaʻamaʻa ikaika a palekana i ka holoholona hoʻokolohua.Ua ʻike ʻia e hoʻokiʻekiʻe i ka hoʻokuʻu ʻana o ka glucose i ka hepatic, kahi e hoʻonui ai i ka hyperglycemia.
Mechanism o ka hana

Kūʻai ʻia ʻo Xylazine e like me kāna paʻakai hydrochloride e like me Rompun (100 mg/mL) a me Anased (20 mg/mL) injectable solutions no ka hoʻokele intravenous i nā lio a me nā ʻīlio.Hiki ke hoʻohuli ʻia nā hana o ka xylazine e ka lawelawe ʻana i ka yohimbine, kahi alkaloid indolalkylamine, e poloka ana i kēlā mau α2-adrenoreceptors i hoʻoulu ʻia e xylazine.
Palapala Palekana

ʻAi ʻona ma ka ʻai ʻana, subcutaneous, a me nā ala intravenous.Nā hopena ʻōnaehana kanaka: hoʻololi i ka hana kaʻa, hāʻule i ke koko, miosis, pleural thickening, pulse rate emi, somnolence.Ke hoʻomehana ʻia a hiki i ka palaho, hoʻopuka ʻo ia i nā uahi ʻawaʻawa o NOx a me SOx