Hua kemika Bromazolam CAS 71368-80-4
ʻIkepili kumu
Huina molekala: C17H13BrN4
- Ka helu hehee: 272.0-275 ℃
- Puni paila: 519.8±60.0 °C(Wānana ʻia)
- mānoanoa: 1.54±0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37±0.40(Wanamua)
- Ke Kumu Molekala: C17H13BrN4
- Kaumaha Molekala: 353.21600
- Nuipa pololei: 352.03200
- PSA: 43.07000
- LogP: 3.12480
Hoʻohana
Hoʻokaʻawale ʻia ʻo Bromazolam ma ke ʻano he benzodiazepine hou i hana mua ʻia ma 1976, akā ʻaʻole i kūʻai ʻia.Ua kūʻai ʻia ʻo ia ma ke ʻano he lāʻau hoʻolālā, ʻike mua ʻia e ka EMCDDA ma Suedena ma 2016. ʻO ia ka bromo ma kahi o ka chloro analogue o alprazolam, a ua like nā hopena sedative a me anxiolytic.ʻO ka Bromazolam keʻano like me nā benzodiazepines kahiko, me ka alprazolam (hoʻololi i ka chlorine me ka bromine) a me ka bromazepam (hoʻohui i ke apo triazole).ʻO Alprazolam a me ka bromazepam nā mea hōʻike IV ma United States;ʻAʻole i hoʻonohonoho pono ʻia ka bromazolam.
Hoʻohana ʻia ʻo 8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a][1,4] benzodiazepine e aʻo i ka hana antianxiety, antidepressant a me psychotropics no ka ʻōnaehana nerve waena.
Hana Hoʻomākaukau
Ua mālama ʻia lākou me ka pHLS9 (2 mg protein / mL), 25 μg/mL Alamethicin (UGT reaction mixture B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, a me 0.6 mM ma 37° C NADP +, 0.9 U/mL isocitrate dehydrogenase, 100 U/mL superoxide dismutase a me 0.1 mM acetyl-CoA.A laila, 2.5 mM UDP-glucuronic acid (UGT reaction mixture solution A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, a me 50 μM clobromazolam a i ʻole Bromazolam i hoʻohui ʻia.
Nā Kūlana Pane:50 μM Bromazolam no 360min ma 37°C
Nā noi:ʻO nā metabolites Bromazolamʻike ʻiai ka pHLS9 incubation.